These hand-driven PYREX®; tissue grinders are supplied with two pestles to ensure dissociation of cells into fine particles with minimal damage to cell nuclei. Dounce homogenizers are particularly useful in enzyme studies where heat build-up must be avoided.

• The internal diameter at the bottom of the unground glass tube (mortar) is .435"± .001"
• Use the large clearance "A" pestle for initial reduction of soft tissue. The diameter of the ground and polished end is .4305"± .0005" for a nominal clearance of .0045" with the tube.
• Complete the homogenization with the small clearance "B" pestle. The diameter of the ground and polished end is .4325"± .0005" for a nominal clearance of .0025" with the tube.